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The menace of plasmids continues to arouse research interest especially as it is harbored by diverse bacterial strains in unpredictable nexus. This study was designed to investigate the antibiogram and presence of High-Molecular-Weight-plasmids (HMW-Plasmids) in heavy metal resistant bacteria in saw-dust dump sites in some wood industries in Sapele, Delta State, Nigeria. A total of ten (10) samples were collected from about 10cm depth in different locations of sawmills in Sapele, Delta State. Plasmid analysis and antibiotic-heavy metal resistance was tested by subjecting recovered isolates to the following concentration of the heavy metals: 0.302mM, 0.604mM, 0.906mM and 1.2mM of Pb; 0.515mM, 1.03mM, 1.54mM and 2.06mM of Cr and 0.435mM, 0.87mM, 1.304mM and 1.74mM of Cd for both pre- and post-curing respectively. A total of seven (7) bacteria species comprising of four (4) Gram positive (Staphylococcus aureus, Bacillus cereus, Cellulomonas sp. and Micrococcus sp.) and three (3) Gram negative bacteria (Salmonella sp., Pseudomonas aeruginosa and Escherichia coli) species were isolated. The heavy metals resistance of the isolates was observed to decrease with increasing concentration of the heavy metals. A total of sixteen (16) multi drug resistances (MDR – resistance to three (3) or more classes of antibiotics) of the isolates were also observed. However, after the isolates were cured of plasmids, the isolates became susceptible to all the tested concentrations of Pb, Cr and Cd. Antibiotics resistance still persist in some of the isolates (Pseudomonas sp., Bacillus sp. and Salmonella sp.), but these observed responses were far less compared to those before the isolates were cured of plasmids, indicating that the antibiotics and heavy metal resistance observed among strains was plasmid mediated. The isolation of antibiotics-heavy metal resistant Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Micrococcus sp., Salmonella sp., Staphylococcus aureus and Cellulomonas sp. is of utmost health importance as these bacteria may pose serious threat to public health, especially to those working in the wood processing industries in Delta State, Nigeria. It is therefore suggested that, efforts should be made by all workers in these wood industries to put on inter-personal protective equipment’s during work hours. The government should also develop policy on the management of such wood wastes release to void spread of such strains in diverse nexus