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THERAPEUTIC POTENTIAL OF CURCUMIN IN ARTHRITIS MANAGEMENT: MECHANISMS OF ACTION, SAFETY PROFILE, AND EXPERIMENTAL INSIGHTS

Authored By: Ogbonnaya, F. C, Nwobi J. C., Ugwu J. C., Ajuzie N. C., Ogunbiyi, B. T., Abimbola O. M.

Article Number: 1729807487

Received Date: October 15th 2024 Published Date: October 24th 2024

Copyright © 2020 Author(s) retain the copyright of this article.

Chronic inflammatory diseases are now a major health concern as they cause a large number of death cases. It is therefore important to control inflammation using anti-inflammatory compounds that are safe and affordable. Many studies suggest that many compounds derived from plants have anti-inflammatory effects; one of which is Curcumin. Curcumin is a principal constituent of turmeric; which has high potential in improving chronic inflammatory disease with less side effects. A large number of studies have proven that curcumin has broad variety of biological functions; anti-inflammatory, anti-oxidant, wound-healing, anti-cancer and anti-arthritis, among which anti-inflammatory effect is a significant feature. This paper reviews the mechanism of action of curcumin on arthritis, safety and toxicity of curcumin, its bio-availability and experimental findings on curcumin’s effect on arthritis; the latest research result on pharmacokinetics of curcumin. Curcumin has an anti-inflammatory effect by suppressing the action of pro-inflammatory cytokines such as interleukins, phospholipase A2, 5-lipoxygenase enzyme and cyclooxygenase-2. Curcumin has been proven to be safe and can be used as an agent to manage and treat arthritis.

 

Ogbonnaya, F. C., Nwobi, J. C., Ugwu, J. C., Ajuzie, N. C., Ogunbiyi, B. T. & Abimbola, O. M. (2024). Therapeutic potential of curcumin in arthritis management: mechanisms of action, safety profile, and experimental insights. Journal of Science, Technology, and Education (JSTE); www.nsukjste.com/ 8(9), 96-106

Ogbonnaya, F. C
Babcock University, School of Basic Medical Sciences, Department of Biochemistry, Ilisan-Remo, Ogun State, PMB 21244, Ikeja-Lagos.
Nwobi J. C.
Department of Biochemistry, School of Basic Sciences, Benjamin S Carson (Snr.) College of Health and Medical Sciences, Babcock Univesity, Ilishan-Remo Ogun State.
Ugwu J. C.
Department of Biochemistry, School of Basic Sciences, Benjamin S Carson (Snr.) College of Health and Medical Sciences, Babcock Univesity, Ilishan-Remo Ogun State.
Ajuzie N. C.
Department of Nutrition and Dietetics, College of Basic Medical Sciences, Babcock University, Ilishan-Remo, Ogun State
Ogunbiyi, B. T.
Department of Biochemistry, School of Basic Sciences, Benjamin S Carson (Snr.) College of Health and Medical Sciences, Babcock Univesity, Ilishan-Remo Ogun State.
Abimbola O. M.
Department of Biochemistry, School of Basic Sciences, Benjamin S Carson (Snr.) College of Health and Medical Sciences, Babcock Univesity, Ilishan-Remo Ogun State.